The Brain Runs on Fat: Revisiting the Preferred Fuel of Human Evolution

For decades, we've been told that glucose is the primary—and preferred—fuel for the human brain. But what if that story is incomplete? Emerging research and a deeper look at our evolutionary biology suggest that ketones—not glucose—may be the brain’s true super fuel, especially in states of fasting, endurance, or low carbohydrate availability.

🦴 A Look Back: Human Evolution and Energy

Our ancestors didn’t eat every 3 hours. Instead, they evolved to thrive in environments where food availability was unpredictable, and long stretches without carbohydrate were common. During those times, the body would enter nutritional ketosis, converting fat into ketone bodies like beta-hydroxybutyrate (BHB)—which are not just an alternative fuel, but in many ways a superior one.

• Persistence hunting (chasing prey for hours): fueled by fat, not carbs.
• Rapid brain growth in Homo erectus: likely supported by nutrient-dense, fatty animal foods.
• Periods of scarcity: ketones preserved cognitive function even when glycogen stores were low.

🧪 The Research: Ketones & Brain Function

✅ Ketones as a More Efficient Fuel

Compared to glucose, ketone metabolism yields more ATP per unit of oxygen.”
— Cunnane et al., 2020, Frontiers in Physiology

This means that ketones may deliver more brain energy per breath, making them especially advantageous during endurance exercise or fasting.

🧠 Cognitive Enhancement

• BHB acts as both fuel and a signaling molecule, promoting brain-derived neurotrophic factor (BDNF).
• Ketogenic diets show benefits in Alzheimer’s, epilepsy, and mild cognitive impairment.

Ketones appear to modulate neurotransmitter balance, reduce oxidative stress, and support mitochondrial efficiency."
— Newman & Verdin, 2022, Cell Metabolism

🏃‍♂️ The Endurance Connection: Fat for Thought and Fuel

As a fat-fuelled runner, you’re not just challenging mainstream nutrition—you’re aligning with millions of years of human physiology. During long, low-intensity efforts (like MAF-based training), the body naturally turns to fat and ketones.

Why this matters:

• Fat-adapted runners report steadier energy, less mental fog, and reduced hunger.
• Ketone metabolism spares glycogen, preserving it for high-intensity bursts.

And if your brain is humming on ketones too? That’s a metabolic win-win.

🥩 Fueling for the Brain and the Run

If you're eating an animal-based, low-carb or even carnivore diet, you're likely spending more time in mild to deep ketosis. That doesn’t just fuel your runs—it may sharpen your thinking, improve recovery, and support long-term brain health.

Quick tips to stay brain-fat-fuelled:

• Eat enough fat (especially saturated and monounsaturated)
• Train at low intensities to promote fat adaptation
• Avoid sugar “top-ups” that knock you out of ketosis
• Consider time-restricted feeding to enhance metabolic flexibility

🔍 Final Thought

The idea that the brain needs carbs is outdated. Yes, glucose can be used—but ketones might be what your brain wants. From evolutionary logic to cutting-edge research, one thing is clear:

When you fuel with fat, you’re not compromising your brain—you’re optimising it.

🧠 References:

1. Cunnane, S. et al. (2020). "Ketones: Metabolism's Secret Weapon." Frontiers in Physiology
2. Newman, J. & Verdin, E. (2022). "Beta-hydroxybutyrate: Much More Than a Metabolite." Cell Metabolism
3. Raichlen, D. & Pontzer, H. (2021). "Endurance, Evolution and the Brain." Nature Reviews Endocrinology